About the Role

A pioneering, early-stage biotech is seeking a Senior Medical Director to lead clinical development for its innovative oncology programmes. This is a rare opportunity to join a small, highly agile team, shape strategy from first in human through proof of concept, and make a tangible impact on the development of next generation cancer therapies.

Key Responsibilities

• Lead the design and execution of early phase clinical programmes, including first in human and phase 1 studies

• Own clinical protocols and synopses, guiding them from concept through to final version

• Define clinical strategy and endpoints aligned with regulatory expectations and scientific objectives

• Establish and maintain robust safety oversight frameworks, including engagement with safety committees

• Provide medical leadership across internal teams and external partners, operating independently when required

• Collaborate closely with clinical operations, biomarker, and translational science colleagues to ensure integrated programme delivery

• Prepare clinical input for regulatory submissions and scientific communications

• Represent clinical programmes in cross-functional meetings and to key external stakeholders

• Mentor and support junior clinical staff, fostering a collaborative, high-performance culture

Essential Experience and Skills

• At least six years’ experience in clinical development with direct responsibility for early phase, first-in-human programmes

• Proven ability to develop clinical plans, synopses, and protocols in oncology or immunotherapy

• Experience in safety oversight and management of safety committees or data monitoring processes

• Comfortable working in a fast-paced, small company setting and operating autonomously

• Strong collaborator, able to manage internal teams and external vendors effectively

• Exceptional written and verbal communication skills, with experience producing clear clinical documents for regulators and investigators

• Medical degree with relevant post-graduate clinical experience; advanced or specialist qualifications preferred

Desirable

• Experience with RNA-based therapies or therapeutic vaccines

• Familiarity with European or Nordic clinical networks

• Experience preparing regulatory submissions for early phase oncology trials

Why This Role is Exciting

• Lead clinical strategy at a senior level within a nimble, innovative biotech

• Influence multiple early stage programmes and shape the future of cancer therapies

• Work closely with a highly motivated team and external scientific collaborators

• Flexible UK or Denmark-based role with occasional travel to investigators and partners